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Medicinal Chemistry of Neglected and Tropical Diseases: Advances in
the Design and Synthesis of Antimicrobial Agents consolidates and
describes modern drug discovery and development approaches
currently employed to identify effective chemotherapeutic agents
for the treatment of Neglected Tropical Diseases (NTDs) from a
medicinal chemistry perspective. Chapters are designed to cater to
the needs of medicinal chemists who work with chemotherapeutic
developments for NTDs, as well as serve as a guide to budding
medicinal chemists who wish to work in this area. It will introduce
rational drug design approaches adopted in designing
chemotherapeutics and validated targets available for the purpose.
"Taken together, the body of information contained in this book
provides readers with a bird's-eye view of different aspects of
exciting work at the convergence of disciplines that will
ultimately lead to a future where we understand how immunity is
regulated, and how we can harness this knowledge toward practical
ends that reduce human suffering. I commend the editors for putting
this volume together." -Arup K. Chakraborty, Robert T. Haslam
Professor of Chemical Engineering, and Professor of Physics,
Chemistry, and Biological Engineering, Massachusetts Institute of
Technology, Cambridge, USA New experimental techniques in
immunology have produced large and complex data sets that require
quantitative modeling for analysis. This book provides a complete
overview of computational immunology, from basic concepts to
mathematical modeling at the single molecule, cellular, organism,
and population levels. It showcases modern mechanistic models and
their use in making predictions, designing experiments, and
elucidating underlying biochemical processes. It begins with an
introduction to data analysis, approximations, and assumptions used
in model building. Core chapters address models and methods for
studying immune responses, with fundamental concepts clearly
defined. Readers from immunology, quantitative biology, and applied
physics will benefit from the following: Fundamental principles of
computational immunology and modern quantitative methods for
studying immune response at the single molecule, cellular,
organism, and population levels. An overview of basic concepts in
modeling and data analysis. Coverage of topics where mechanistic
modeling has contributed substantially to current understanding.
Discussion of genetic diversity of the immune system, cell
signaling in the immune system, immune response at the cell
population scale, and ecology of host-pathogen interactions.
Provides easy-to-follow flow charts that serve as procedural guide
for scene investigations in most major types of crimes Presents the
variety of different types of observable evidence encountered in
real-life cases to inform scene investigators Offers methods for
framing multiple hypotheses, using specific case examples, to
factor in various considerations in crime scene reconstruction
scenarios The discussion following each chapter forms a compendium
of generalizations accepted in scholarly sources-a key enabler when
testing the hypotheses
"Taken together, the body of information contained in this book
provides readers with a bird's-eye view of different aspects of
exciting work at the convergence of disciplines that will
ultimately lead to a future where we understand how immunity is
regulated, and how we can harness this knowledge toward practical
ends that reduce human suffering. I commend the editors for putting
this volume together." -Arup K. Chakraborty, Robert T. Haslam
Professor of Chemical Engineering, and Professor of Physics,
Chemistry, and Biological Engineering, Massachusetts Institute of
Technology, Cambridge, USA New experimental techniques in
immunology have produced large and complex data sets that require
quantitative modeling for analysis. This book provides a complete
overview of computational immunology, from basic concepts to
mathematical modeling at the single molecule, cellular, organism,
and population levels. It showcases modern mechanistic models and
their use in making predictions, designing experiments, and
elucidating underlying biochemical processes. It begins with an
introduction to data analysis, approximations, and assumptions used
in model building. Core chapters address models and methods for
studying immune responses, with fundamental concepts clearly
defined. Readers from immunology, quantitative biology, and applied
physics will benefit from the following: Fundamental principles of
computational immunology and modern quantitative methods for
studying immune response at the single molecule, cellular,
organism, and population levels. An overview of basic concepts in
modeling and data analysis. Coverage of topics where mechanistic
modeling has contributed substantially to current understanding.
Discussion of genetic diversity of the immune system, cell
signaling in the immune system, immune response at the cell
population scale, and ecology of host-pathogen interactions.
Provides easy-to-follow flow charts that serve as procedural guide
for scene investigations in most major types of crimes Presents the
variety of different types of observable evidence encountered in
real-life cases to inform scene investigators Offers methods for
framing multiple hypotheses, using specific case examples, to
factor in various considerations in crime scene reconstruction
scenarios The discussion following each chapter forms a compendium
of generalizations accepted in scholarly sources-a key enabler when
testing the hypotheses
Medicinal Chemistry of Neglected and Tropical Diseases: Advances in
the Design and Synthesis of Antimicrobial Agents consolidates and
describes modern drug discovery and development approaches
currently employed to identify effective chemotherapeutic agents
for the treatment of Neglected Tropical Diseases (NTDs) from a
medicinal chemistry perspective. Chapters are designed to cater to
the needs of medicinal chemists who work with chemotherapeutic
developments for NTDs, as well as serve as a guide to budding
medicinal chemists who wish to work in this area. It will introduce
rational drug design approaches adopted in designing
chemotherapeutics and validated targets available for the purpose.
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India and Pan-Islamism
Bhimrao Ambedkar, Jagath Jayaprakash
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R450
Discovery Miles 4 500
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Ships in 10 - 15 working days
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